5-Fluorinated L-lysine analogues as selective induced nitric oxide synthase inhibitors

J Med Chem. 2004 Feb 12;47(4):900-6. doi: 10.1021/jm030348f.

Abstract

5(S)-Fluoro-N6-(iminoethyl)-l-lysine (14), an analogue of the potent, selective induced nitric oxide synthase (iNOS) inhibitor iminoethyl-l-lysine (1), was synthesized and found to be a selective iNOS inhibitor.

MeSH terms

  • Crystallography, X-Ray
  • Isoenzymes / antagonists & inhibitors
  • Isoenzymes / chemistry
  • Lysine / analogs & derivatives
  • Lysine / chemical synthesis*
  • Lysine / chemistry
  • Models, Molecular
  • Nitric Oxide Synthase / antagonists & inhibitors*
  • Nitric Oxide Synthase / chemistry
  • Nitric Oxide Synthase Type II

Substances

  • 5-fluoro-N6-(iminoethyl)lysine
  • Isoenzymes
  • Nitric Oxide Synthase
  • Nitric Oxide Synthase Type II
  • Lysine