Microwave accelerated facile synthesis of fused polynuclear hydrocarbons in dry media by intramolecular Friedel-Crafts alkylation

Org Biomol Chem. 2004 Feb 21;2(4):514-23. doi: 10.1039/b311750m. Epub 2004 Jan 21.

Abstract

Fused polynuclear tetrahydro arenes are synthesised in a fast, simple, high yielding and regiospecific procedure by an intramolecular Friedel-Crafts alkylation in dry media under microwave irradiation of the corresponding 1-bromo-4-arylbutanes immobilised on silica. The observed reactivity is rationalised by molecular modelling studies which suggest the occurrence of a concerted mechanism.