Abstract
A large gastric lymphoma was detected in a 42-year-old woman who was seropositive for HTLV-I. The tumor was histologically shown to be of diffuse large cell type, and phenotypic analysis revealed high expression of CD3 and CD4, indicative of a helper/inducer type of T-cell lymphoma. In Southern blot analyses, the tumor cells showed T-cell receptor re-arrangement and contained proviral DNA of HTLV-1.
MeSH terms
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Adult
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Blotting, Southern
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DNA, Viral / analysis
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DNA, Viral / genetics
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Female
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Gene Rearrangement, T-Lymphocyte
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Human T-lymphotropic virus 1 / genetics
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Human T-lymphotropic virus 1 / isolation & purification*
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Humans
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Leukemia-Lymphoma, Adult T-Cell / genetics
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Leukemia-Lymphoma, Adult T-Cell / immunology
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Leukemia-Lymphoma, Adult T-Cell / microbiology
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Leukemia-Lymphoma, Adult T-Cell / pathology*
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Proviruses / genetics
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Proviruses / isolation & purification*
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Restriction Mapping
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Stomach Neoplasms / genetics
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Stomach Neoplasms / immunology
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Stomach Neoplasms / microbiology
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Stomach Neoplasms / pathology*