The effect of cyclophosphamide administration on the kidney of the rat

Toxicol Lett. 1992 Dec;63(3):261-76. doi: 10.1016/0378-4274(92)90089-3.

Abstract

In studies primarily designed to evaluate the effectiveness of chitosan as a treatment for cyclophosphamide-induced hemorrhagic cystitis in the rat, renal papillary necrosis and pyelonephritis were observed. Cyclophosphamide alone produced relatively mild renal changes. The combination of cyclophosphamide and intravesical instillation of acetic acid induced renal papillary necrosis (38 to 83% incidence) along with pyelonephritis, hydroureter and hydronephrosis. Chitosan, instilled in place of acetic acid, partially inhibited the induction of renal papillary necrosis. It appears that the presence of vesico-ureteral reflux with or without associated hydroureter and hydronephrosis is a prerequisite for cyclophosphamide-induced renal damage.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acetates / toxicity
  • Acetic Acid
  • Animals
  • Chitin / analogs & derivatives
  • Chitin / therapeutic use
  • Chitosan
  • Cyclophosphamide / toxicity*
  • Female
  • Hemostatics / therapeutic use
  • Hydronephrosis / chemically induced
  • Kidney / drug effects*
  • Kidney Papillary Necrosis / chemically induced*
  • Kidney Papillary Necrosis / prevention & control
  • Male
  • Random Allocation
  • Rats
  • Rats, Inbred F344

Substances

  • Acetates
  • Hemostatics
  • Chitin
  • Cyclophosphamide
  • Chitosan
  • Acetic Acid