The use of chondrogide membrane in autologous chondrocyte implantation

Knee. 2004 Feb;11(1):51-5. doi: 10.1016/S0968-0160(03)00041-3.

Abstract

Autologous chondrocyte implantation is a new technique for the treatment of chondral defects in the knee. The exact procedure involved is continuously being developed with the ultimate aim of achieving hyaline cartilage regeneration. We present the outcome of our series of 31 patients, focussing on the use of the chondrogide membrane in the implantation process. Assessment is presented both in the form of arthroscopic appearance at approximately 1 year, and in the form of clinical outcome measures at 1 year and at 2 years after the second stage of the procedure.

Conclusion: the use of chondrogide membrane in the fixation of cells during the implantation process is associated with satisfactory clinical outcome and does not appear to show evidence of hypertrophy at one-year arthroscopy, as compared to periosteum.

Publication types

  • Clinical Trial

MeSH terms

  • Adolescent
  • Adult
  • Animals
  • Biocompatible Materials
  • Cartilage, Articular / injuries
  • Cartilage, Articular / surgery
  • Cell Transplantation / methods*
  • Cells, Cultured / transplantation
  • Chondrocytes / cytology
  • Chondrocytes / transplantation*
  • Female
  • Humans
  • Knee Injuries / physiopathology
  • Knee Injuries / therapy*
  • Knee Joint / pathology
  • Knee Joint / physiopathology
  • Knee Joint / surgery
  • Male
  • Membranes, Artificial*
  • Middle Aged
  • Prospective Studies
  • Swine
  • Transplantation, Autologous
  • Treatment Outcome
  • Wound Healing

Substances

  • Biocompatible Materials
  • Membranes, Artificial