Statin-associated rhabdomyolysis triggered by grapefruit consumption

Neurology. 2004 Feb 24;62(4):670. doi: 10.1212/wnl.62.4.670.
No abstract available

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Anticholesteremic Agents / adverse effects*
  • Anticholesteremic Agents / pharmacokinetics
  • Citrus paradisi / adverse effects*
  • Cytochrome P-450 CYP3A
  • Cytochrome P-450 Enzyme Inhibitors
  • Enzyme Inhibitors / adverse effects
  • Enzyme Inhibitors / pharmacology
  • Female
  • Furocoumarins / adverse effects
  • Furocoumarins / pharmacology
  • Humans
  • Hyperlipoproteinemia Type II / drug therapy
  • Inactivation, Metabolic
  • Rhabdomyolysis / chemically induced*
  • Simvastatin / adverse effects*
  • Simvastatin / pharmacokinetics

Substances

  • Anticholesteremic Agents
  • Cytochrome P-450 Enzyme Inhibitors
  • Enzyme Inhibitors
  • Furocoumarins
  • Simvastatin
  • CYP3A protein, human
  • Cytochrome P-450 CYP3A