Current developments in the discovery and design of new drug candidates from plant natural product leads

J Nat Prod. 2004 Feb;67(2):273-83. doi: 10.1021/np030373o.

Abstract

This review article will emphasize recent research in the Natural Products Laboratory, School of Pharmacy, University of North Carolina at Chapel Hill, on various classes of plant-derived compounds that possess potent antitumor or anti-HIV activity. These compounds were obtained by bioactivity- and mechanism of action-directed isolation and characterization coupled with rational drug design-based modification and analogue synthesis. Structural modification, SAR, and mechanism of action studies are discussed.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Anti-HIV Agents / chemistry*
  • Anti-HIV Agents / pharmacology*
  • Antineoplastic Agents / chemistry*
  • Antineoplastic Agents / pharmacology*
  • Biological Factors / chemistry*
  • Biological Factors / pharmacology*
  • Drug Design
  • Molecular Structure
  • Plants, Medicinal / chemistry*
  • Structure-Activity Relationship

Substances

  • Anti-HIV Agents
  • Antineoplastic Agents
  • Biological Factors