Effect of combined statin and beta-blocker treatment on one-year morbidity and mortality after acute myocardial infarction associated with heart failure

Aina Hognestad; Kenneth Dickstein; Eivind Myhre; Steven Snapinn; John Kjekshus; OPTIMAAL Investigators

doi:10.1016/j.amjcard.2003.11.027

Effect of combined statin and beta-blocker treatment on one-year morbidity and mortality after acute myocardial infarction associated with heart failure

Am J Cardiol. 2004 Mar 1;93(5):603-6. doi: 10.1016/j.amjcard.2003.11.027.

Authors

Aina Hognestad¹, Kenneth Dickstein, Eivind Myhre, Steven Snapinn, John Kjekshus; OPTIMAAL Investigators

Affiliation

¹ Department of Cardiology, Rikshospitalet, University of Oslo, Oslo, Norway. ina.hognestad@klinmed.uio.no

PMID: 14996587
DOI: 10.1016/j.amjcard.2003.11.027

Abstract

This retrospective, nonrandomized analysis evaluated the effect of initiating statin or beta-blocker treatment early in the course of heart failure developed during acute myocardial infarction compared with the effect of neither or both treatments. Early initiation of statins or beta blockers alone was associated with improved event-free survival, and the benefits of the combined treatment were additive.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Adrenergic beta-Antagonists / administration & dosage*
Aged
Aged, 80 and over
Disease-Free Survival
Drug Therapy, Combination
Female
Heart Failure / complications*
Heart Failure / drug therapy*
Heart Failure / mortality
Humans
Hydroxymethylglutaryl-CoA Reductase Inhibitors / administration & dosage*
Male
Middle Aged
Myocardial Infarction / complications*
Myocardial Infarction / drug therapy*
Myocardial Infarction / mortality
Retrospective Studies
Time Factors

Substances

Adrenergic beta-Antagonists
Hydroxymethylglutaryl-CoA Reductase Inhibitors