Comparative evaluation of D-dimer assays for exclusion of deep venous thrombosis in symptomatic outpatients

Thromb Res. 2003;112(1-2):25-32. doi: 10.1016/j.thromres.2003.11.002.

Abstract

Diagnostic work-up of patients sent to the hospital for diagnosing of deep venous thrombosis (DVT) often combines the determination of D-dimer and the application of a clinical probability score. To fulfill diagnostic as well as economic needs, D-dimer assays should exhibit a high negative predictive value (NPV) as well as reasonable specificity. In this study, we evaluated both a latex-enhanced immunoassay for use on routine coagulation analyzers and a radial partition immunoassay (RPIA) for use on a point-of-care analyzer. Samples included were from 344 outpatients with suspected deep venous thrombosis. Among them, 100 had deep venous thrombosis. Results obtained for both assays show a good efficiency for exclusion of deep venous thrombosis with well-acceptable specificity.

Publication types

  • Comparative Study
  • Evaluation Study
  • Validation Study

MeSH terms

  • Decision Support Techniques
  • Diagnosis, Computer-Assisted / methods*
  • Diagnosis, Differential
  • Fibrin Fibrinogen Degradation Products / analysis*
  • Humans
  • Leg / blood supply
  • Radioimmunoassay / instrumentation
  • Radioimmunoassay / methods*
  • Reproducibility of Results
  • Risk Assessment / methods*
  • Sensitivity and Specificity
  • Venous Thrombosis / blood*
  • Venous Thrombosis / diagnosis*

Substances

  • Fibrin Fibrinogen Degradation Products
  • fibrin fragment D