Translocation (11;13)(q23;q14) as the sole abnormality in a childhood de novo acute myelocytic leukemia

Cancer Genet Cytogenet. 2004 Apr 1;150(1):78-80. doi: 10.1016/j.cancergencyto.2003.08.016.

Abstract

We report a case of childhood de novo acute myelocytic leukemia (AML) with hyperleukocytosis with monoblastic features and deranged hemostasic function. G-band karyotyping demonstrated a previously unreported t(11;13)(q23;q14) in metaphase preparations from a fluorodeoxyuridine synchronized 1-day culture of leukophoresed cells. Multicolor fluorescence in situ hybridization revealed no cryptic rearrangements except for the translocation. Reverse transcriptase polymerase chain reaction showed no concomitant positivity of AML1/ETO, BCR/ABL, PML/RARA, and CBFbeta/MYH11 resulting from t(8;21)(q22;q22), t(9;22)(q34;q11), t(15;17)(q22;q11), and inv(16) (p13q22), respectively. This report of childhood de novo AML harboring t(11;13)(q23;q14) as the sole cytogenetic abnormality provides more data on the leukemogenesis of de novo AML with a 11q23 rearrangement.

Publication types

  • Case Reports

MeSH terms

  • Biomarkers, Tumor / genetics
  • Child
  • Chromosome Aberrations*
  • Chromosome Banding
  • Chromosomes, Human, Pair 11 / genetics*
  • Chromosomes, Human, Pair 13 / genetics*
  • Female
  • Gene Rearrangement
  • Humans
  • In Situ Hybridization, Fluorescence
  • Karyotyping
  • Leukemia, Myeloid, Acute / genetics*
  • Reverse Transcriptase Polymerase Chain Reaction
  • Translocation, Genetic*

Substances

  • Biomarkers, Tumor