A genetic algorithm for the detection of new cis-regulatory modules in sets of coregulated genes

Stein Aerts; Peter Van Loo; Yves Moreau; Bart De Moor

doi:10.1093/bioinformatics/bth179

A genetic algorithm for the detection of new cis-regulatory modules in sets of coregulated genes

Bioinformatics. 2004 Aug 12;20(12):1974-6. doi: 10.1093/bioinformatics/bth179. Epub 2004 Mar 25.

Authors

Stein Aerts¹, Peter Van Loo, Yves Moreau, Bart De Moor

Affiliation

¹ Department of Electrical Engineering (ESAT-SCD), Katholieke Universiteit Leuven, Kasteelpark Arenberg 10, 3001 Heverlee (Leuven), Belgium. stein.aerts@esat.kuleuven.ac.be

PMID: 15044242
DOI: 10.1093/bioinformatics/bth179

Abstract

Summary: The implementation of a genetic algorithm is described that provides a fast method of searching for the optimal combination of transcription factor binding sites in a set of regulatory sequences.

Availability: The algorithm can be used transparently as a web service from within the Toucan software. Toucan can be accessed at http://www.esat.kuleuven.ac.be/~saerts/software/toucan.php. A standalone version of the software is available upon request.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Algorithms*
Chromosome Mapping / methods*
Gene Expression Profiling / methods*
Gene Expression Regulation / genetics*
Genes, Regulator / genetics*
Models, Genetic
Sequence Alignment / methods*
Sequence Analysis, DNA / methods*
Software