Co-existence of Philadelphia chromosome positive acute megakaryoblastic and B-lymphoblastic mixed blast crisis of chronic myeloid leukemia with chronic lymphocytic leukemia

Eur J Haematol. 2004 May;72(5):361-5. doi: 10.1111/j.1600-0609.2004.00222.x.

Abstract

In this study, we describe an extremely rare case of co-existence of a Philadelphia chromosome positive acute megakaryoblastic and B-lymphoblastic mixed blast crisis of chronic myeloid leukemia with chronic lymphocytic leukemia. A morphological, immunophenotypical and cytogenetic study has been performed to characterize the case and in order to identify the origin of two disorders. After the failure of the conventional therapy, the patient was treated with Imatinib with a complete hematological and cytogenetic response and a marked reduction of bone marrow fibrosis.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Aged
  • Antineoplastic Combined Chemotherapy Protocols / therapeutic use
  • Benzamides
  • Blast Crisis* / genetics
  • Blast Crisis* / pathology
  • Burkitt Lymphoma* / genetics
  • Burkitt Lymphoma* / pathology
  • Cytarabine / administration & dosage
  • Daunorubicin / administration & dosage
  • Female
  • Humans
  • Imatinib Mesylate
  • Immunophenotyping
  • Karyotyping
  • Leukemia, Lymphocytic, Chronic, B-Cell* / genetics
  • Leukemia, Lymphocytic, Chronic, B-Cell* / pathology
  • Leukemia, Megakaryoblastic, Acute* / genetics
  • Leukemia, Megakaryoblastic, Acute* / pathology
  • Leukemia, Myelogenous, Chronic, BCR-ABL Positive* / genetics
  • Leukemia, Myelogenous, Chronic, BCR-ABL Positive* / pathology
  • Neoplasms, Multiple Primary* / genetics
  • Neoplasms, Multiple Primary* / pathology
  • Piperazines / therapeutic use
  • Pyrimidines / therapeutic use
  • Remission Induction

Substances

  • Benzamides
  • Piperazines
  • Pyrimidines
  • Cytarabine
  • Imatinib Mesylate
  • Daunorubicin