SN2 vs. E2 on quaternary centres: an application to the synthesis of enantiopure beta2,2-amino acids

Chem Commun (Camb). 2004 Apr 21:(8):980-1. doi: 10.1039/b400282b. Epub 2004 Mar 16.

Abstract

S(N)2 and E2 competing reactions in cyclic sulfamidates can be modulated by the change of an amide group to an ester group attached to the quaternary carbon activated for the nucleophilic attack, allowing an easy approach to enantiopure alpha,alpha-disubstituted beta-amino acids.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acids / chemical synthesis*
  • Esters / chemistry
  • Fluorides / chemistry
  • Molecular Structure
  • Stereoisomerism
  • Sulfonamides / chemistry

Substances

  • Amino Acids
  • Esters
  • Sulfonamides
  • Fluorides