Influence of PAMAM dendrimers on human red blood cells

Bioelectrochemistry. 2004 Jun;63(1-2):189-91. doi: 10.1016/j.bioelechem.2003.09.023.

Abstract

Polyamidoamine (PAMAM) dendrimers with different concentrations (1 nM-1 mM) (generations 2, 3, and 4) impact on human red blood cell morphology, and membrane integrity is studied. Erythrocyte shape changes from biconcave to echinocytic in dendrimers. Cell aggregation occurs. Polymers cause also concentration- and generation-dependent haemolysis.

Publication types

  • Comparative Study

MeSH terms

  • Cell Size / drug effects*
  • Cells, Cultured
  • Dimerization
  • Dose-Response Relationship, Drug
  • Erythrocyte Membrane / drug effects
  • Erythrocyte Membrane / physiology
  • Erythrocytes / cytology*
  • Erythrocytes / drug effects*
  • Hemolysis / drug effects*
  • Humans
  • Polyamines / classification
  • Polyamines / pharmacology*
  • Polymers / pharmacology

Substances

  • Polyamines
  • Polymers