A new entry to Amaryllidaceae alkaloids from carbohydrates: total synthesis of (+)-vittatine

Chem Commun (Camb). 2004 May 7:(9):1086-7. doi: 10.1039/b402762k. Epub 2004 Mar 30.

Abstract

The stereoselective and chiral synthesis of the Amaryllidaceae alkaloid, (+)-vittatine 1, is described; the quaternary carbon in 1 was generated by Claisen rearrangement of a cyclohexenol derived from D-glucose by way of a Ferrier's carbocyclisation reaction and a hexahydroindole skeleton was effectively constructed by intramolecular aminomercuration-demercuration, followed by Chugaev reaction.

MeSH terms

  • Alkaloids / chemical synthesis*
  • Alkaloids / chemistry*
  • Carbohydrates / chemistry*
  • Cyclization
  • Molecular Structure
  • Phenanthridines / chemical synthesis*
  • Phenanthridines / chemistry*
  • Stereoisomerism

Substances

  • Alkaloids
  • Carbohydrates
  • Phenanthridines
  • vittatine 1