New start and finish for complex polyketide biosynthesis

Patrick Caffrey

doi:10.1016/j.chembiol.2004.02.002

New start and finish for complex polyketide biosynthesis

Chem Biol. 2004 Feb;11(2):155-7. doi: 10.1016/j.chembiol.2004.02.002.

Author

Patrick Caffrey¹

Affiliation

¹ Department of Industrial Microbiology, Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Dublin 4, Ireland.

PMID: 15123275
DOI: 10.1016/j.chembiol.2004.02.002

Abstract

The polyketide vicenistatin has significant anticancer activity. In the January issue of Chemistry & Biology, Kakinuma and coworkers reported on the vicenistatin biosynthetic gene cluster and demonstrated in vitro glycosylation of its aglycone core, raising the possibility of producing analogs with altered sugar residues.

Publication types

Comment

MeSH terms

Aminoglycosides / biosynthesis*
Aminoglycosides / chemical synthesis
Aminoglycosides / chemistry*
Animals
Antineoplastic Agents / chemical synthesis
Antineoplastic Agents / chemistry*
Antineoplastic Agents / metabolism*
Lactams / chemical synthesis
Lactams / chemistry*
Macrolides / chemical synthesis
Macrolides / chemistry*

Substances

Aminoglycosides
Antineoplastic Agents
Lactams
Macrolides
vicenistatin