MAPPP: MHC class I antigenic peptide processing prediction

Appl Bioinformatics. 2003;2(3):155-8.

Abstract

MAPPP is a bioinformatics tool for the prediction of potential antigenic epitopes presented on the cell surface by major histocompatibility complex class I (MHC I) molecules to CD8 positive T lymphocytes. It combines existing predictions for proteasomal cleavage with peptide anchoring to MHC I molecules.

Publication types

  • Evaluation Study
  • Research Support, Non-U.S. Gov't
  • Validation Study

MeSH terms

  • Algorithms*
  • Antigen Presentation / immunology
  • Cysteine Endopeptidases / chemistry
  • Cysteine Endopeptidases / immunology
  • Database Management Systems
  • Epitopes, T-Lymphocyte / chemistry*
  • Epitopes, T-Lymphocyte / immunology*
  • Histocompatibility Antigens Class I / analysis*
  • Histocompatibility Antigens Class I / chemistry*
  • Information Storage and Retrieval / methods
  • Models, Chemical
  • Multienzyme Complexes / chemistry
  • Multienzyme Complexes / immunology
  • Peptides / chemistry
  • Peptides / immunology
  • Proteasome Endopeptidase Complex
  • Protein Binding
  • Protein Interaction Mapping / methods*
  • Sequence Analysis, Protein / methods*
  • Software*
  • Structure-Activity Relationship
  • User-Computer Interface

Substances

  • Epitopes, T-Lymphocyte
  • Histocompatibility Antigens Class I
  • Multienzyme Complexes
  • Peptides
  • Cysteine Endopeptidases
  • Proteasome Endopeptidase Complex