Abstract
The cycloSal-concept is one example of a successful nucleotide delivering system (pronucleotide). For several nucleoside analogues, the cycloSal-approach improved the antiviral potency and the applicability of the nucleosides could be broadened. Here, a conceptional extension of the original design of the cycloSal-system will be discussed.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Antiviral Agents / chemistry*
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Antiviral Agents / pharmacology
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Cell Division / drug effects
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Dideoxynucleotides
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Humans
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Molecular Structure
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Nucleotides / chemistry*
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Nucleotides / pharmacology
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Prodrugs / chemistry*
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Prodrugs / pharmacology
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Stavudine / analogs & derivatives*
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Stavudine / chemical synthesis
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Stavudine / chemistry*
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Stavudine / pharmacology
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Structure-Activity Relationship
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Thymine Nucleotides
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Viruses / drug effects
Substances
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Antiviral Agents
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Cyclosaligenyl-2',3'-didehydro-2',3'-dideoxythymidine monophosphate
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Dideoxynucleotides
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Nucleotides
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Prodrugs
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Thymine Nucleotides
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Stavudine