T cell receptor delta-chain gene rearrangement in a novel case of adult NK cell leukemia

Acta Haematol. 2004;111(4):225-7. doi: 10.1159/000077571.

Abstract

Malignancies arising from natural killer (NK) cells are being increasingly recognized as distinct clinicopathological entities. We here report the characteristics of a peculiar case of NK-cell acute leukemia with unusual agranular morphology and rearrangement of the T-cell receptor (TCR) delta-chain gene.

Publication types

  • Case Reports

MeSH terms

  • Acute Disease
  • Aged
  • Antigens, CD / analysis
  • Bone Marrow Examination
  • Gene Rearrangement, delta-Chain T-Cell Antigen Receptor*
  • Genes, T-Cell Receptor delta / genetics
  • Humans
  • Killer Cells, Natural / pathology*
  • Killer Cells, Natural / ultrastructure
  • Leukemia, Lymphoid / genetics*
  • Leukemia, Lymphoid / pathology
  • Leukemia, T-Cell / genetics*
  • Leukemia, T-Cell / pathology
  • Male

Substances

  • Antigens, CD