Checkpoint adaptation; molecular mechanisms uncovered

Patrick J Lupardus; Karlene A Cimprich

doi:10.1016/j.cell.2004.05.005

Checkpoint adaptation; molecular mechanisms uncovered

Cell. 2004 May 28;117(5):555-6. doi: 10.1016/j.cell.2004.05.005.

Authors

Patrick J Lupardus¹, Karlene A Cimprich

Affiliation

¹ Stanford University, Department of Molecular Pharmacology, 318 Campus Drive, Stanford, CA 94305, USA.

PMID: 15163402
DOI: 10.1016/j.cell.2004.05.005

Abstract

Adaptation to the DNA damage checkpoint is a phenomenon long thought to be confined to the unicellular world. A new report in this issue of Cell by suggests the presence of a checkpoint adaptation pathway in Xenopus egg extracts that displays interesting molecular parallels to adaptation in yeast.

Publication types

Comment

MeSH terms

Animals
Cell Cycle / physiology*
Cell Cycle Proteins / metabolism
Checkpoint Kinase 2
Genes, cdc*
Intracellular Signaling Peptides and Proteins
Protein Serine-Threonine Kinases / metabolism
Saccharomyces cerevisiae / metabolism
Saccharomyces cerevisiae Proteins / metabolism
Xenopus

Substances

Cell Cycle Proteins
Intracellular Signaling Peptides and Proteins
Saccharomyces cerevisiae Proteins
Checkpoint Kinase 2
MEC1 protein, S cerevisiae
Protein Serine-Threonine Kinases
RAD53 protein, S cerevisiae