Abstract
Utilizing a human cytomegalovirus-specific fusion inhibitor and an antiglycoprotein H antibody, we studied the role of virion fusion in interferon-stimulated gene (ISG) induction. Our results indicate that ISG induction does not occur when virion-mediated, post-high-affinity attachment events are inhibited by either reagent. Thus, virion-mediated postattachment events, such as fusion, are required for ISG induction.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Cells, Cultured
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Cytomegalovirus / metabolism
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Cytomegalovirus / pathogenicity*
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Fibroblasts
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Gene Expression Regulation*
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Humans
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Interferons / pharmacology*
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Membrane Fusion* / drug effects
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Proteins / genetics
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Proteins / metabolism
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Viral Envelope Proteins / metabolism
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Virion / metabolism
Substances
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Proteins
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Viral Envelope Proteins
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glycoprotein H, Cytomegalovirus
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glycoprotein H, Human cytomegalovirus
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Interferons