The mRNA cap-binding protein eIF4E in post-transcriptional gene expression

Nat Struct Mol Biol. 2004 Jun;11(6):503-11. doi: 10.1038/nsmb779.

Abstract

Eukaryotic initiation factor 4E (eIF4E) has central roles in the control of several aspects of post-transcriptional gene expression and thereby affects developmental processes. It is also implicated in human diseases. This review explores the relationship between structural, biochemical and biophysical aspects of eIF4E and its function in vivo, including both long-established roles in translation and newly emerging ones in nuclear export and mRNA decay pathways.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Active Transport, Cell Nucleus
  • Eukaryotic Initiation Factor-4E / chemistry
  • Eukaryotic Initiation Factor-4E / metabolism
  • Eukaryotic Initiation Factor-4E / physiology*
  • Gene Expression Regulation*
  • Protein Binding
  • Protein Biosynthesis
  • RNA Cap-Binding Proteins / chemistry
  • RNA Cap-Binding Proteins / metabolism
  • RNA Cap-Binding Proteins / physiology*
  • RNA Stability

Substances

  • Eukaryotic Initiation Factor-4E
  • RNA Cap-Binding Proteins