Pseudodeflectusin, a novel isochroman derivative from Aspergillus pseudodeflectus a parasite of the sea weed, Sargassum fusiform, as a selective human cancer cytotoxin

Bioorg Med Chem Lett. 2004 Jul 5;14(13):3539-43. doi: 10.1016/j.bmcl.2004.04.050.

Abstract

A new isochroman derivative named pseudodeflectusin was isolated from a culture broth of Aspergillus pseudodeflectus. The structure was determined by spectroscopic means as 9-hydroxy-7-methyl-2-(methylethylidine)-furano[3,2-H]isochroman-3-one. This compound exhibited cytotoxicity for several human cancer cell lines from the stomach (NUGC-3), cervix (HeLa-S3), and peripheral blood (HL-60), but did not affect those from the lung (A549) or colon (DLD-1). The LD50 value of this compound for HL-60 cells was 39 microM.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antineoplastic Agents, Phytogenic / chemistry
  • Antineoplastic Agents, Phytogenic / isolation & purification*
  • Antineoplastic Agents, Phytogenic / pharmacology
  • Aspergillus / chemistry*
  • Chromans / chemistry
  • Chromans / isolation & purification*
  • Chromans / pharmacology
  • Eukaryota / microbiology*
  • Female
  • Glutathione / metabolism
  • HL-60 Cells
  • HeLa Cells
  • Humans
  • Male
  • Molecular Structure
  • Tumor Cells, Cultured

Substances

  • Antineoplastic Agents, Phytogenic
  • Chromans
  • pseudodeflectusin
  • Glutathione