Synthesis and antileukemic activity of new 3-(5-methylisoxazol-3-yl) and 3-(pyrimidin-2-yl)-2-styrylquinazolin-4(3H)-ones

Farmaco. 2004 Jun;59(6):451-5. doi: 10.1016/j.farmac.2003.10.006.

Abstract

3-(3-Methylisoxazol-5-yl) and 3-(pyrimidin-2-yl)-2-styrylquinazolin-4(3H)-ones 8a-l and 9a,c-e,h-l were synthesized by refluxing in acetic acid the corresponding 2-methylquinazolinones 6 and 8 with the opportune benzoic aldehyde for 12 h. The synthesized styrylquinazolinones 8a-l and 9a,c-e,h-l were tested in vitro for their antileukemic activity against L-1210 (murine leukemia), K-562 (human chronic myelogenous leukemia) and HL-60 (human leukemia) cell lines showing in some cases good activity.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antineoplastic Agents / chemical synthesis*
  • Antineoplastic Agents / pharmacology
  • Antineoplastic Agents / therapeutic use*
  • Colchicine / pharmacology
  • Czech Republic
  • Drug Evaluation, Preclinical / methods
  • HL-60 Cells
  • Humans
  • K562 Cells
  • Leukemia L1210
  • Molecular Structure
  • Oxazoles / chemical synthesis*
  • Oxazoles / pharmacology
  • Oxazoles / therapeutic use
  • Quinazolines / chemical synthesis*
  • Quinazolines / pharmacology
  • Quinazolines / therapeutic use

Substances

  • 3-(5-methylisoxazol-3-yl)-2-styrylquinazolin-4(3H)-one
  • Antineoplastic Agents
  • Oxazoles
  • Quinazolines
  • Colchicine