Tipping the scales of selection with BAFF

Immunity. 2004 Jun;20(6):655-6. doi: 10.1016/j.immuni.2004.06.001.

Abstract

Two recent Immunity papers link peripheral tolerance with the ability of developing B cells to capture BAFF. These findings suggest that an increase in effective BAFF levels leads to autoreactive B cell maturation.

Publication types

  • Comment

MeSH terms

  • B-Cell Activating Factor
  • B-Lymphocytes / cytology
  • B-Lymphocytes / immunology*
  • B-Lymphocytes / metabolism*
  • Cell Differentiation
  • Immune Tolerance*
  • Membrane Proteins / metabolism*
  • Tumor Necrosis Factor-alpha / metabolism*

Substances

  • B-Cell Activating Factor
  • Membrane Proteins
  • Tumor Necrosis Factor-alpha