Vascular endothelial growth factor-A, vascular endothelial growth factor receptor-2 and angiopoietin-2 expression in the mouse choroid plexuses

Beatrice Nico; Domenica Mangieri; Patrizia Corsi; Michela De Giorgis; Angelo Vacca; Luisa Roncali; Domenico Ribatti

doi:10.1016/j.brainres.2004.04.016

Vascular endothelial growth factor-A, vascular endothelial growth factor receptor-2 and angiopoietin-2 expression in the mouse choroid plexuses

Brain Res. 2004 Jul 9;1013(2):256-9. doi: 10.1016/j.brainres.2004.04.016.

Authors

Beatrice Nico¹, Domenica Mangieri, Patrizia Corsi, Michela De Giorgis, Angelo Vacca, Luisa Roncali, Domenico Ribatti

Affiliation

¹ Department of Human Anatomy and Histology, University of Bari Medical School, Piazza Giulio Cesare, 11, Policlinico, I-70124, Bari, Italy.

PMID: 15193536
DOI: 10.1016/j.brainres.2004.04.016

Abstract

In this study, for the first time, we investigated about the localization of VEGF-A, VEGFR-2 and Ang-2 in the choroid plexuses of the adult mouse by Western blot and immunohistochemistry. Results showed that VEGF-A stained epithelial cells, while anti-VEGFR-2 and -Ang-2 antibodies stained endothelial cells. These data suggest that Ang-2, converting blood vessels into a more plastic and immature phenotype, would provide more accessibility of VEGF-A to endothelial cells.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Age Factors
Angiopoietin-2 / metabolism*
Animals
Choroid Plexus / metabolism*
Immunohistochemistry
Mice
Vascular Endothelial Growth Factor A / metabolism*
Vascular Endothelial Growth Factor Receptor-2 / metabolism*

Substances

Angiopoietin-2
Vascular Endothelial Growth Factor A
Vascular Endothelial Growth Factor Receptor-2