Abstract
Objective:
To study the effect of helicobacter pylori on gastric mucosal cell proliferation in gastritis.
Methods:
Fifty-six gastritis patients with or without Helicobacter pylori infection (Hp+ 27; Hp- 29) were selected. The expression of proliferation cell nuclear antigen (PCNA), epidermal growth factor receptor (EGFR), transforming growth factor beta receptor type I and type II(TGFbetaRI, TGFbetaRII) in gastric mucosa were examined by immunohistochemical method.
Results:
The PCNA and EGFR were significantly higher in Hp positive chronic gastritis patients than in Hp negative ones(P<0.05); The TGFbetaRI(P=0.16) and TGFbetaRII(P=0.97) were lower.
Conclusion:
Hp infection promotes over proliferation of gastric mucosal cells.
MeSH terms
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Activin Receptors, Type I / analysis
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Adult
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Aged
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Cell Division
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ErbB Receptors / analysis
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Female
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Gastric Mucosa / pathology*
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Gastritis
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Helicobacter Infections / metabolism
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Helicobacter Infections / pathology*
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Helicobacter pylori*
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Humans
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Male
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Middle Aged
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Proliferating Cell Nuclear Antigen / analysis
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Protein Serine-Threonine Kinases
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Receptor, Transforming Growth Factor-beta Type I
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Receptor, Transforming Growth Factor-beta Type II
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Receptors, Transforming Growth Factor beta / analysis
Substances
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Proliferating Cell Nuclear Antigen
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Receptors, Transforming Growth Factor beta
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ErbB Receptors
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Protein Serine-Threonine Kinases
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Activin Receptors, Type I
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Receptor, Transforming Growth Factor-beta Type I
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Receptor, Transforming Growth Factor-beta Type II