Abstract
The metabolism of the basal ganglia was examined by using proton magnetic resonance spectroscopy in 5 neonates with severe hyperbilirubinemia. A decreased N-acetylaspartate/choline ratio, indicating neuronal injury, and an abnormally high lactate/N-acetylaspartate ratio were found only in the neonate with neonatal magnetic resonance imaging abnormalities and subsequent cerebral palsy.
MeSH terms
-
Aspartic Acid / analogs & derivatives*
-
Aspartic Acid / metabolism
-
Basal Ganglia / metabolism*
-
Bilirubin / blood
-
Cerebral Palsy / etiology
-
Choline / metabolism
-
Evoked Potentials, Auditory, Brain Stem
-
Humans
-
Infant, Newborn
-
Jaundice, Neonatal / complications
-
Jaundice, Neonatal / metabolism*
-
Lactic Acid / blood
-
Lactic Acid / metabolism
-
Magnetic Resonance Imaging
-
Magnetic Resonance Spectroscopy
Substances
-
Aspartic Acid
-
Lactic Acid
-
N-acetylaspartate
-
Choline
-
Bilirubin