Progestin-induced fatty acid synthetase in human mammary tumors: from molecular to clinical studies

J Steroid Biochem Mol Biol. 1992 Sep;43(1-3):223-8. doi: 10.1016/0960-0760(92)90211-z.

Abstract

Fatty acid synthetase (FAS) is one of the first well-characterized progestin-induced proteins with available antibodies and cDNA. This paper reviews basic studies on FAS regulation in human breast cancer cell lines and recent data on the possible clinical significance of this new marker of hormone responsiveness in mammary cancer and benign breast diseases.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Biomarkers, Tumor / genetics
  • Biomarkers, Tumor / metabolism
  • Breast Neoplasms / enzymology*
  • Enzyme Induction
  • Fatty Acid Synthases / genetics
  • Fatty Acid Synthases / metabolism*
  • Gene Expression Regulation, Enzymologic
  • Gene Expression Regulation, Neoplastic
  • Humans
  • Progestins / pharmacology*
  • Progestins / physiology
  • Receptors, Progesterone / metabolism

Substances

  • Biomarkers, Tumor
  • Progestins
  • Receptors, Progesterone
  • Fatty Acid Synthases