[Superficial siderosis of the CNS. Case report and literature review]

Nervenarzt. 2004 May;75(5):492-5. doi: 10.1007/s00115-003-1600-8.
[Article in German]

Abstract

Superficial siderosis of the central nervous system is caused by destructive deposition of haemosiderin in the leptomeninges and subpial layers of the brain and spinal cord. This deposition is the result of continuous or recurrent, often clinically silent, haemorrhage in the subarachnoid space, eventually without an evident bleeding source. Cerebellar ataxia, progressive bilateral sensorineural hearing loss, pyramidal tract signs, and dementia are the major clinical findings. The diagnosis is supported in vivo by the characteristic symptom constellation,xanthochromic cerebrospinal fluid,and typical MRI findings which show on the surface of the brainstem, cerebellum, cortex, and spinal cord. Early recognition of this rare entity may be of relevance for the further course and prognosis.

Publication types

  • Case Reports
  • English Abstract
  • Review

MeSH terms

  • Aged
  • Central Nervous System Diseases / cerebrospinal fluid
  • Central Nervous System Diseases / complications*
  • Central Nervous System Diseases / diagnosis*
  • Diagnosis, Differential
  • Hearing Loss, Sensorineural / cerebrospinal fluid
  • Hearing Loss, Sensorineural / diagnosis*
  • Hearing Loss, Sensorineural / etiology*
  • Humans
  • Magnetic Resonance Imaging / methods*
  • Male
  • Siderosis / cerebrospinal fluid
  • Siderosis / complications*
  • Siderosis / diagnosis*