The C-glycoside analogue of the immunostimulant alpha-galactosylceramide (KRN7000): synthesis and striking enhancement of activity

Angew Chem Int Ed Engl. 2004 Jul 19;43(29):3818-22. doi: 10.1002/anie.200454215.
No abstract available

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adjuvants, Immunologic / chemical synthesis*
  • Adjuvants, Immunologic / therapeutic use
  • Animals
  • Antineoplastic Agents / chemical synthesis
  • Antineoplastic Agents / therapeutic use
  • Cytotoxicity, Immunologic
  • Dose-Response Relationship, Drug
  • Galactosylceramides / chemical synthesis*
  • Galactosylceramides / immunology
  • Galactosylceramides / therapeutic use
  • Glycosides
  • Liver Neoplasms, Experimental / drug therapy
  • Liver Neoplasms, Experimental / metabolism
  • Lung / metabolism
  • Melanoma, Experimental / drug therapy
  • Mice
  • Monosaccharides / chemical synthesis*
  • Sporozoites / drug effects
  • Sporozoites / metabolism

Substances

  • Adjuvants, Immunologic
  • Antineoplastic Agents
  • C-glycoside
  • Galactosylceramides
  • Glycosides
  • Monosaccharides
  • KRN 7000