Isoniazid and hypoglycaemia in a premature infant

J Paediatr Child Health. 2004 Aug;40(8):490-2. doi: 10.1111/j.1440-1754.2004.00438.x.

Abstract

Severe hypoglycaemia requiring more than 20 mg/kg per minute glucose infusion was seen in a premature infant. The infant was born to a woman with active tuberculosis, and she was on prophylactic isoniazid. Discontinuation of isoniazid resulted in prompt recovery of hypoglycaemia. Further pharmacological studies may be needed to establish a cause and effect relationship.

Publication types

  • Case Reports

MeSH terms

  • Antibiotics, Antitubercular / adverse effects*
  • Antibiotics, Antitubercular / therapeutic use
  • Female
  • Humans
  • Hypoglycemia / chemically induced*
  • Infant, Newborn
  • Infant, Premature
  • Infant, Very Low Birth Weight
  • Intensive Care Units, Neonatal
  • Isoniazid / adverse effects*
  • Isoniazid / therapeutic use
  • Time Factors
  • Treatment Outcome
  • Tuberculosis / drug therapy*

Substances

  • Antibiotics, Antitubercular
  • Isoniazid