Abstract
Securamine A is a structurally intriguing alkaloid possessing a pyrroloindole core joined via a modified isoprene subunit to a functionalized imidazole ring. Recent synthetic efforts in this laboratory have resulted in the efficient construction of key lactone 36, which undergoes tandem azide reduction/ring expansion to macrolactam 37. Macrolactam 37 possesses the complete macrocyclic core of securamine A.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, Non-P.H.S.
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Animals
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Biological Products / chemical synthesis
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Biological Products / chemistry
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Bryozoa / chemistry
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Chemistry, Organic / methods
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Indole Alkaloids / chemical synthesis*
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Indole Alkaloids / chemistry*
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Molecular Structure
Substances
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Biological Products
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Indole Alkaloids