Abstract
A palladium--phosphinous acid-catalyzed Sonogashira cross-coupling reaction that proceeds in water under air atmosphere in the absence of organic co-solvents has been developed. Disubstituted alkynes have been prepared in up to 91% yield by POPd-catalyzed coupling of various aryl halides including chlorides in the presence of tetrabutylammonium bromide and pyrrolidine or NaOH.
MeSH terms
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Air
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Alkynes / chemistry
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Atmosphere
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Catalysis
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Chlorides / chemistry
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Cross Reactions
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Hydrocarbons, Halogenated / chemistry
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Organic Chemicals
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Palladium / chemistry*
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Phosphorus Acids / chemistry*
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Pyrrolidines / chemistry
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Quaternary Ammonium Compounds / chemistry
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Sodium Hydroxide / chemistry
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Solvents / chemistry
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Water / chemistry*
Substances
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Alkynes
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Chlorides
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Hydrocarbons, Halogenated
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Organic Chemicals
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Phosphorus Acids
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Pyrrolidines
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Quaternary Ammonium Compounds
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Solvents
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Water
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Sodium Hydroxide
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Palladium
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tetrabutylammonium
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pyrrolidine