Abstract
In this article, we briefly review the structural and functional information currently available on nucleoplasmin. Special emphasis is placed on the discussion of the molecular mechanism involved in the sperm chromatin remodelling activity of this protein. A model is proposed based on current crystallographic data, recent biophysical and functional studies, as well as in the previously available information.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Active Transport, Cell Nucleus
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Animals
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Cell Nucleus / metabolism*
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Chromatin / metabolism
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Crystallography, X-Ray
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Drosophila
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Drosophila Proteins
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Humans
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Male
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Models, Biological
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Models, Molecular
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Molecular Chaperones / metabolism*
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Nuclear Proteins / metabolism
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Nuclear Proteins / physiology*
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Nucleoplasmins
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Phosphoproteins / metabolism
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Phosphoproteins / physiology*
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Phosphorylation
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Protein Conformation
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Spermatozoa / metabolism
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Xenopus
Substances
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Chromatin
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Drosophila Proteins
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Molecular Chaperones
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Nlp protein, Drosophila
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Nuclear Proteins
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Nucleoplasmins
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Phosphoproteins