Highly efficient dendrimer-based mimic of glutathione peroxidase

Xi Zhang; Huaping Xu; Zeyuan Dong; Yapei Wang; Junqiu Liu; Jiacong Shen

doi:10.1021/ja048890w

Highly efficient dendrimer-based mimic of glutathione peroxidase

J Am Chem Soc. 2004 Sep 1;126(34):10556-7. doi: 10.1021/ja048890w.

Authors

Xi Zhang¹, Huaping Xu, Zeyuan Dong, Yapei Wang, Junqiu Liu, Jiacong Shen

Affiliation

¹ Key Lab of Organic Optoelectronics & Molecular Engineering, Department of Chemistry, Tsinghua University, Beijing 100084, P. R. China. xi@mail.tsinghua.edu.cn

PMID: 15327310
DOI: 10.1021/ja048890w

Abstract

In this communication, we report the synthesis of the three generations of Fréchet-type poly(aryl ether) dendrimers with a diselenide core that demonstrate generation-dependent glutathione peroxidase (GPx) activity with initial reduction rates as high as 2431.20 muM min-1 for the third-generation product, around 1400 times faster than Ebselen. It represents a successful example of using a dendrimer as a model for a GPx mimic.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Benzene Derivatives / chemical synthesis
Benzene Derivatives / chemistry
Biomimetic Materials / chemical synthesis*
Biomimetic Materials / chemistry
Ethers / chemical synthesis
Ethers / chemistry*
Glutathione Peroxidase / chemistry*
Glutathione Peroxidase / metabolism
Polymers / chemical synthesis*
Polymers / chemistry

Substances

Benzene Derivatives
Ethers
Polymers
Glutathione Peroxidase