Arginine methylation regulates the cytokine response

Mol Cell. 2004 Aug 27;15(4):492-4. doi: 10.1016/j.molcel.2004.08.011.

Abstract

The recent identification of the NFAT-interacting protein NIP45 as a methylated protein by marks a new role for protein arginine methylation in lymphocyte signaling and cytokine gene activation.

Publication types

  • Comment

MeSH terms

  • Arginine / metabolism*
  • Carrier Proteins / metabolism
  • Cytokines / immunology
  • Cytokines / metabolism*
  • DNA-Binding Proteins / metabolism
  • Gene Expression Regulation*
  • Intracellular Signaling Peptides and Proteins*
  • Methylation
  • NFATC Transcription Factors
  • Nuclear Proteins / metabolism
  • Protein-Arginine N-Methyltransferases / metabolism
  • Signal Transduction / physiology
  • T-Lymphocytes / immunology
  • T-Lymphocytes / metabolism
  • Transcription Factors / metabolism
  • Transcriptional Activation

Substances

  • Carrier Proteins
  • Cytokines
  • DNA-Binding Proteins
  • Intracellular Signaling Peptides and Proteins
  • NFATC Transcription Factors
  • Nfatc2ip protein, mouse
  • Nuclear Proteins
  • Transcription Factors
  • Arginine
  • Protein-Arginine N-Methyltransferases