MHC and non-MHC gene regulation of disease susceptibility and disease course in experimental inflammatory peripheral neuropathy

J Neuroimmunol. 2004 Oct;155(1-2):73-84. doi: 10.1016/j.jneuroim.2004.06.001.

Abstract

With a panel of rat strains, we demonstrate a strong impact of the MHC genotype on susceptibility and disease course in experimental autoimmune neuritis induced with peripheral nerve myelin or the P2 peptide 58-81 (KNTEISFKLGQEFEETTADNRKTK). Beside the MHC genotype, non-MHC genes determined disease susceptibility and resistance. The type of disease induced with P2 58-81 was strongly correlated to the strength of the MHC class II isotype interaction with P2 58-81. These findings suggest a link between susceptibility and acute versus chronic disease courses on one hand and the strength of the MHC class II molecule/peptide affinity on the other hand.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Chronic Disease
  • Disease Models, Animal
  • Gene Expression Regulation / genetics*
  • Gene Expression Regulation / immunology
  • Genetic Predisposition to Disease / genetics*
  • Genotype
  • Guillain-Barre Syndrome / genetics*
  • Guillain-Barre Syndrome / immunology
  • Guillain-Barre Syndrome / physiopathology
  • Haplotypes / genetics
  • Histocompatibility Antigens / genetics*
  • Histocompatibility Antigens / immunology
  • Histocompatibility Antigens Class II / genetics
  • Histocompatibility Antigens Class II / immunology
  • Male
  • Myelin P2 Protein / immunology
  • Myelin Sheath / immunology
  • Neuritis, Autoimmune, Experimental / genetics*
  • Neuritis, Autoimmune, Experimental / immunology
  • Neuritis, Autoimmune, Experimental / physiopathology
  • Peptide Fragments / immunology
  • Peripheral Nervous System Diseases / genetics*
  • Peripheral Nervous System Diseases / immunology
  • Protein Binding / genetics
  • Protein Binding / immunology
  • Rats
  • Rats, Inbred Lew
  • Rats, Inbred Strains
  • Species Specificity

Substances

  • Histocompatibility Antigens
  • Histocompatibility Antigens Class II
  • Myelin P2 Protein
  • Peptide Fragments