Thunderclap headache and reversible segmental cerebral vasoconstriction associated with use of oxymetazoline nasal spray

CMAJ. 2004 Sep 14;171(6):593-4. doi: 10.1503/cmaj.1040631.

Abstract

Oxymetazoline is a sympathomimetic amine found in over-the-counter nasal decongestants. We report a case of chronic use of nasal oxymetazoline associated with thunderclap headache due to reversible segmental intracranial vasoconstriction.

Publication types

  • Case Reports

MeSH terms

  • Administration, Intranasal
  • Adult
  • Brain / blood supply*
  • Drug Administration Schedule
  • Female
  • Headache / chemically induced*
  • Headache / physiopathology*
  • Humans
  • Nasal Decongestants / administration & dosage
  • Nasal Decongestants / adverse effects*
  • Oxymetazoline / administration & dosage
  • Oxymetazoline / adverse effects*
  • Vasoconstriction / physiology*

Substances

  • Nasal Decongestants
  • Oxymetazoline