Abstract
Outcome of PPARgamma activation in cancer cells is not one-dimensional. PPARgamma signaling is dependent upon PPARgamma ligand affinity and binding characteristics, target cell context and interacting signaling networks.
MeSH terms
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Animals
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Antineoplastic Agents / chemistry
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Antineoplastic Agents / pharmacology*
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Antineoplastic Agents / therapeutic use
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Cell Differentiation / drug effects
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Cell Line, Tumor
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Cell Proliferation / drug effects
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Colorectal Neoplasms / drug therapy
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Colorectal Neoplasms / metabolism
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Colorectal Neoplasms / pathology
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Humans
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Ligands
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PPAR gamma / agonists*
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PPAR gamma / metabolism
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Signal Transduction / drug effects*
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Structure-Activity Relationship
Substances
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Antineoplastic Agents
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Ligands
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PPAR gamma