Enantioselective aldol reaction of trimethoxysilyl enol ether catalyzed by lithium binaphtholate

Org Lett. 2004 Oct 14;6(21):3763-5. doi: 10.1021/ol048485+.

Abstract

[reaction: see text] An aldol reaction of trimethoxysilyl enol ether catalyzed by lithium binaphtholate, in which water serves as an additive and plays a pivotal role in stereoselectivities, was developed. This is the first example of an aldol reaction of trimethoxysilyl enol ether catalyzed by a chiral base.