Antibiotic resistance may affect alkali decontamination of specimens containing mycobacteria

Hasan Yesilkaya; Michael R Barer; Peter W Andrew

doi:10.1016/j.diagmicrobio.2004.06.015

Antibiotic resistance may affect alkali decontamination of specimens containing mycobacteria

Diagn Microbiol Infect Dis. 2004 Oct;50(2):153-5. doi: 10.1016/j.diagmicrobio.2004.06.015.

Authors

Hasan Yesilkaya¹, Michael R Barer, Peter W Andrew

Affiliation

¹ Department of Infection, Immunity, and Inflammation, Leicester Medical School, University of Leicester, United Kingdom. hy3@le.ac.uk

PMID: 15474327
DOI: 10.1016/j.diagmicrobio.2004.06.015

Abstract

The influence of genetic modification on the decontamination process of mycobacteria was investigated using a wild type Mycobacterium bovis BCG Pasteur and its isogenic mutant strain. The result showed that the killing effect of sodium hydroxide (NaOH) progressively increased with prolonged incubation (up to 20 minutes), and the deteriorating effect of NaOH was more severe on the genetically modified strain.

Publication types

Comparative Study
Research Support, Non-U.S. Gov't

MeSH terms

Animals
Anti-Bacterial Agents / pharmacology*
Bacteriological Techniques*
Decontamination
Drug Resistance, Bacterial
Humans
Microbial Sensitivity Tests
Mycobacterium bovis / drug effects*
Mycobacterium bovis / genetics
Mycobacterium bovis / isolation & purification
Sampling Studies
Sensitivity and Specificity
Sodium Hydroxide / pharmacology*

Substances

Anti-Bacterial Agents
Sodium Hydroxide