Abstract
Several studies in childhood acute lymphoblastic leukemia (ALL) have documented that molecular detection of minimal residual disease (MRD) based on screening for T-cell receptor and immunoglobulin gene rearrangements can identify patients at a high risk of relapse. In our experience, evaluation of MRD in adult ALL can help to identify high risk patients.
Publication types
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Letter
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Research Support, Non-U.S. Gov't
MeSH terms
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Adolescent
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Adult
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Bone Marrow Examination
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DNA, Neoplasm / genetics
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Disease-Free Survival
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Female
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Gene Rearrangement, B-Lymphocyte, Light Chain
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Gene Rearrangement, delta-Chain T-Cell Antigen Receptor
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Gene Rearrangement, gamma-Chain T-Cell Antigen Receptor
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Humans
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Immunoglobulin kappa-Chains / genetics
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Leukemia-Lymphoma, Adult T-Cell / genetics
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Leukemia-Lymphoma, Adult T-Cell / mortality
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Leukemia-Lymphoma, Adult T-Cell / pathology
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Leukemic Infiltration
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Male
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Meninges / pathology
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Middle Aged
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Neoplasm Proteins / genetics
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Neoplasm, Residual
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Polymerase Chain Reaction
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Precursor B-Cell Lymphoblastic Leukemia-Lymphoma / genetics
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Precursor B-Cell Lymphoblastic Leukemia-Lymphoma / mortality
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Precursor B-Cell Lymphoblastic Leukemia-Lymphoma / pathology
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Precursor Cell Lymphoblastic Leukemia-Lymphoma / genetics
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Precursor Cell Lymphoblastic Leukemia-Lymphoma / mortality
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Precursor Cell Lymphoblastic Leukemia-Lymphoma / pathology*
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Receptors, Antigen, T-Cell, gamma-delta / genetics
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Remission Induction
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Reproducibility of Results
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Survival Analysis
Substances
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DNA, Neoplasm
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Immunoglobulin kappa-Chains
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Neoplasm Proteins
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Receptors, Antigen, T-Cell, gamma-delta