A polymorphism of the hypocretin receptor 2 gene is associated with cluster headache

Neurology. 2004 Oct 12;63(7):1286-8. doi: 10.1212/01.wnl.0000142424.65251.db.

Abstract

Several polymorphisms of the hypocretin/orexin system genes were evaluated in 109 cluster headache patients and 211 controls. The 1246 G>A polymorphism of the gene was significantly different between cases and controls. Homozygosity for the G allele was associated with an increased disease risk (OR: 6.79, 95% CI, 2.25 to 22.99). The data suggest that the HCRTR2 gene or a linked locus significantly modulates the risk for cluster headache.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Case-Control Studies
  • Cluster Headache / genetics*
  • Cohort Studies
  • Female
  • Gene Frequency
  • Genotype
  • Humans
  • Male
  • Middle Aged
  • Orexin Receptors
  • Polymorphism, Single Nucleotide
  • Receptors, G-Protein-Coupled
  • Receptors, Neuropeptide / genetics*

Substances

  • Orexin Receptors
  • Receptors, G-Protein-Coupled
  • Receptors, Neuropeptide