Abstract
The preparation and evaluation of novel aryl urea analogs as broad-spectrum antibacterial agents is described. Numerous compounds showed low micromolar minimum inhibitory concentrations (MIC) against both Gram-positive and Gram-negative bacteria. Selected analogs also exhibited in vivo efficacy in a lethal murine model of bacterial septicemia.
Publication types
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Research Support, U.S. Gov't, Non-P.H.S.
MeSH terms
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Anti-Bacterial Agents* / chemical synthesis
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Anti-Bacterial Agents* / pharmacology
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Evaluation Studies as Topic
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Gram-Negative Bacteria / drug effects
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Gram-Negative Bacteria / growth & development
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Gram-Positive Bacteria / drug effects
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Gram-Positive Bacteria / growth & development
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Microbial Sensitivity Tests
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Molecular Structure
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Staphylococcus aureus / drug effects
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Staphylococcus aureus / growth & development
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Structure-Activity Relationship
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Thiourea* / analogs & derivatives
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Thiourea* / chemical synthesis
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Thiourea* / pharmacology
Substances
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Anti-Bacterial Agents
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Thiourea