Plasmid-mediated carbapenem-hydrolyzing enzyme KPC-2 in an Enterobacter sp

Ashfaque Hossain; M J Ferraro; R M Pino; R B Dew 3rd; E S Moland; T J Lockhart; K S Thomson; R V Goering; N D Hanson

doi:10.1128/AAC.48.11.4438-4440.2004

Plasmid-mediated carbapenem-hydrolyzing enzyme KPC-2 in an Enterobacter sp

Antimicrob Agents Chemother. 2004 Nov;48(11):4438-40. doi: 10.1128/AAC.48.11.4438-4440.2004.

Authors

Ashfaque Hossain¹, M J Ferraro, R M Pino, R B Dew 3rd, E S Moland, T J Lockhart, K S Thomson, R V Goering, N D Hanson

Affiliation

¹ Department of Medical Microbiology and Immunology, Creighton University School of Medicine, 2500 California Plaza, Omaha, NE 68178, USA.

Abstract

A strain of an Enterobacter sp. with reduced susceptibility to imipenem, which produced a plasmid-mediated class A carbapenem-hydrolyzing enzyme, KPC-2 beta-lactamase, was isolated from a patient with sepsis at a Boston hospital. This is the first report of the production of a plasmid-encoded KPC-2 beta-lactamase by an Enterobacter sp.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Carbapenems / metabolism*
DNA, Bacterial / genetics
Drug Resistance, Bacterial
Enterobacter / enzymology*
Enterobacter / genetics*
Enterobacteriaceae Infections / microbiology
Escherichia coli / genetics
Humans
Microbial Sensitivity Tests
Phenotype
Plasmids / genetics*
RNA, Ribosomal, 16S / genetics
beta-Lactamases / genetics*
beta-Lactamases / metabolism*

Substances

Carbapenems
DNA, Bacterial
RNA, Ribosomal, 16S
beta-lactamase KPC-2
beta-Lactamases