Abstract
The general preprotein translocase of the outer mitochondrial membrane (TOM complex) transports virtually all mitochondrial precursor proteins, but cannot assemble outer-membrane precursors into functional complexes. A recently discovered sorting and assembly machinery (SAM complex) is essential for integration and assembly of outer-membrane proteins, revealing unexpected connections to mitochondrial evolution and morphology.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Adenosine Triphosphate / metabolism
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Apoptosis
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Cytosol / metabolism
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Fungal Proteins / physiology
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Humans
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Intracellular Membranes / metabolism*
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Mitochondria / metabolism
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Mitochondria / pathology*
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Mitochondrial Proteins / chemistry
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Mitochondrial Proteins / metabolism
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Models, Biological
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Molecular Chaperones / metabolism
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Plant Proteins / metabolism
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Protein Transport
Substances
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Fungal Proteins
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Mitochondrial Proteins
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Molecular Chaperones
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Plant Proteins
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Adenosine Triphosphate