Interpretation of expression-profiling results obtained from different platforms and tissue sources: examples using prostate cancer data

G Chiorino; F Acquadro; M Mello Grand; S Viscomi; R Segir; M Gasparini; P Dotto

doi:10.1016/j.ejca.2004.07.029

Interpretation of expression-profiling results obtained from different platforms and tissue sources: examples using prostate cancer data

Eur J Cancer. 2004 Nov;40(17):2592-603. doi: 10.1016/j.ejca.2004.07.029.

Authors

G Chiorino¹, F Acquadro, M Mello Grand, S Viscomi, R Segir, M Gasparini, P Dotto

Affiliation

¹ Laboratory of Cancer Pharmacogenomics, Fondo Edo Tempia, via Malta 3, Biella 13900, Italy. giovanna.chiorino@fondoedotempia.it

PMID: 15541960
DOI: 10.1016/j.ejca.2004.07.029

Abstract

The analysis of expression signatures is a powerful tool for the classification of cancer and other tissue samples. Several protocols and platforms are available on the market, and these lead to both confirmatory and complementary results. We review the main processing techniques for cross-platform comparisons and the different tissue sources for cancer profiling. Some examples and the cross-interpretation of bibliographic data related to prostate cancer are also presented.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Data Collection / methods*
Data Collection / standards
Data Interpretation, Statistical*
Databases, Bibliographic / standards
Gene Expression Profiling / methods*
Humans
Male
Prostatic Neoplasms / drug therapy*
Prostatic Neoplasms / genetics
RNA, Neoplasm / analysis
Reference Values

Substances

RNA, Neoplasm