Transmission disequilibrium analysis of the GSN gene in a cohort of family trios with schizophrenia

Neurosci Lett. 2004 Dec 6;372(3):200-3. doi: 10.1016/j.neulet.2004.09.041.

Abstract

Apoptosis is thought to play a role in neuronal pathology in schizophrenia. Recently, the GSN gene was reported to have anti-apoptotic properties. In a genome-wide expression analysis on schizophrenia, GSN was also found to be significantly down-regulated in schizophrenia. All the hints suggest that GSN is a novel candidate gene in occurrence of schizophrenia. In this work, we genotyped 3 SNPs around the GSN locus in 493 sets of the Han Chinese trio sample using allele-specific PCR. A weak association or a marginally positive result was detected (0.05 for P-value of the overtransmitted haplotype and 0.02 for a global P-value).

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • China / epidemiology
  • Cohort Studies
  • Female
  • Gelsolin / genetics*
  • Genetic Linkage
  • Genotype
  • Haplotypes
  • Heterozygote
  • Humans
  • Male
  • Polymorphism, Single Nucleotide / genetics
  • Psychiatric Status Rating Scales
  • Reverse Transcriptase Polymerase Chain Reaction
  • Schizophrenia / genetics*
  • Schizophrenic Psychology

Substances

  • Gelsolin