Evaluation of combined live, attenuated respiratory syncytial virus and parainfluenza 3 virus vaccines in infants and young children

J Infect Dis. 2004 Dec 15;190(12):2096-103. doi: 10.1086/425981. Epub 2004 Nov 8.

Abstract

We evaluated a combination respiratory syncytial virus (RSV) and parainfluenza 3 virus (PIV3) live, attenuated intranasal vaccine for safety, viral replication, and immunogenicity in doubly seronegative children 6-18 months old. RSV cpts-248/404 and PIV3-cp45 vaccines were combined in a dose of 10(5) plaque-forming units of each per 0.5-mL dose and compared with monovalent vaccines or placebo. The virus shedding pattern of RSV was not different between monovalent RSV cpts-248/404 vaccine and combination vaccine. Modest reductions in the shedding of PIV3-cp45 vaccine virus were found after the administration of RSV cpts-248/404 and PIV3-cp45 vaccine, relative to monovalent PIV3 vaccine; 16 (76%) of 21 children given combination vaccine shed PIV3-cp45 versus 11 (92%) of 12 of those given monovalent PIV3 vaccine. Both vaccines were immunogenic, and antibody responses were similar between the monovalent groups and the combination group. Combined RSV/PV3 vaccine is feasible for simultaneous administration, and further studies are warranted.

Publication types

  • Clinical Trial
  • Clinical Trial, Phase I
  • Multicenter Study
  • Randomized Controlled Trial
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Administration, Intranasal
  • Antibodies, Viral / blood
  • Double-Blind Method
  • Humans
  • Infant
  • Parainfluenza Vaccines / administration & dosage
  • Parainfluenza Vaccines / adverse effects
  • Parainfluenza Vaccines / immunology*
  • Parainfluenza Virus 3, Human / immunology*
  • Respiratory Syncytial Virus Infections / immunology
  • Respiratory Syncytial Virus Infections / prevention & control
  • Respiratory Syncytial Virus Vaccines / administration & dosage
  • Respiratory Syncytial Virus Vaccines / adverse effects
  • Respiratory Syncytial Virus Vaccines / immunology*
  • Respirovirus Infections / immunology
  • Respirovirus Infections / prevention & control
  • Vaccines, Combined / adverse effects
  • Vaccines, Combined / immunology
  • Virus Shedding

Substances

  • Antibodies, Viral
  • Parainfluenza Vaccines
  • Respiratory Syncytial Virus Vaccines
  • Vaccines, Combined